LMPD Database

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LMP011307

UniProt Annotations

Entry Information
Gene Namesqualene epoxidase 2
Protein EntryERG15_ARATH
UniProt IDO81000
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic ActivitySqualene + NADPH + O(2) = (3S)-2,3-epoxy-2,3- dihydrosqualene + NADP(+) + H(2)O. {ECO:0000269|PubMed:17426032}.
CofactorName=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
FunctionCatalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway. Produces primarily oxidosqualene. {ECO:0000269|PubMed:17426032}.
PathwayTerpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 2/3.
SimilarityBelongs to the squalene monooxygenase family. {ECO:0000305}.
Subcellular LocationMitochondrion membrane {ECO:0000305}; Multi- pass membrane protein {ECO:0000305}.
Tissue SpecificityExpressed mainly in inflorescences. Detected in seedlings, leaves, stems, and siliques. {ECO:0000269|PubMed:17426032}.