LMPD Database

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LMP011308

UniProt Annotations

Entry Information
Gene Namesqualene epoxidase 3
Protein EntryERG16_ARATH
UniProt IDQ8VYH2
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic ActivitySqualene + NADPH + O(2) = (3S)-2,3-epoxy-2,3- dihydrosqualene + NADP(+) + H(2)O. {ECO:0000269|PubMed:17426032}.
CofactorName=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
FunctionCatalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway. Can produce not only oxidosqualene, but also 2,3:22,23-dioxidosqualene. {ECO:0000269|PubMed:17426032}.
PathwayTerpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 2/3.
Sequence CautionSequence=CAB38924.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAB80441.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the squalene monooxygenase family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue SpecificityExpressed in seedlings, leaves, stems, inflorescences and siliques. {ECO:0000269|PubMed:17426032}.