LMPD Database

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LMP011309

UniProt Annotations

Entry Information
Gene Namesqualene monooxygenase 2
Protein EntryERG13_ARATH
UniProt IDO65403
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic ActivitySqualene + NADPH + O(2) = (3S)-2,3-epoxy-2,3- dihydrosqualene + NADP(+) + H(2)O.
CofactorName=FAD; Xref=ChEBI:CHEBI:57692;
FunctionCatalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway.
MiscellaneousSEQ4 or SEQ5 are unable to complement seq1 mutants. {ECO:0000305|PubMed:17426032}.
PathwayTerpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 2/3.
SimilarityBelongs to the squalene monooxygenase family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue SpecificityExpressed mainly in seedlings and inflorescences. {ECO:0000269|PubMed:17426032}.