LMPD Database

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LMP011353

UniProt Annotations

Entry Information
Gene Namethiol-disulfide oxidoreductase LTO1
Protein EntryLTO1_ARATH
UniProt IDQ8L540
SpeciesArabidopsis
Comments
Comment typeDescription
Disruption PhenotypeSevere growth defects due to a limitation in the electron flow from PSII. {ECO:0000269|PubMed:22209765, ECO:0000269|PubMed:23689258}.
FunctionThiol-disulfide oxidoreductase catalyzing disulfide bond formation of chloroplast proteins and involved in redox regulation and photosynthetic electron transport. Required for the assembly of photosystem II (PSII) through the formation of disulfide bond in PSBO, a subunit of the PSII oxygen-evolving complex in the thylakoid lumen. Involved in the formation of disulfide bonds in the lumenal protein FKBP13. In vitro, reduces phylloquinone (vitamin K1) and menaquinone (vitamin K2) to their respective quinol. Cannot reduce phylloquinone epoxide to phylloquinone. {ECO:0000269|PubMed:20626653, ECO:0000269|PubMed:21781282, ECO:0000269|PubMed:22209765, ECO:0000269|PubMed:23689258}.
Sequence CautionSequence=AAM65737.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA20046.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAB81485.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the VKOR family. {ECO:0000305}.
Subcellular LocationPlastid, chloroplast thylakoid membrane {ECO:0000305|PubMed:20626653, ECO:0000305|PubMed:21781282}; Multi- pass membrane protein {ECO:0000305|PubMed:20626653, ECO:0000305|PubMed:21781282}.
SubunitInteracts with the PSII subunits PSBO1 and PSBO2. {ECO:0000269|PubMed:22209765}.
Tissue SpecificityExpressed in cotyledons, rosette leaves, stems, cauline leaves and flowers. {ECO:0000269|PubMed:20626653}.