LMPD Database

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LMP011459

UniProt Annotations

Entry Information
Gene Namevitamin D (1,25- dihydroxyvitamin D3) receptor a
Protein EntryVDRA_DANRE
UniProt IDQ9PTN2
SpeciesZebrafish
Comments
Comment typeDescription
DomainComposed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
FunctionNuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Plays a central role in calcium homeostasis. {ECO:0000269|PubMed:17218092}.
SimilarityBelongs to the nuclear hormone receptor family. NR1 subfamily. {ECO:0000305}.
SimilarityContains 1 nuclear receptor DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00407}.
Subcellular LocationNucleus.
SubunitInteracts with ncoa1 and possibly other coactivators, leading to a strong increase of transcription of target genes. {ECO:0000269|PubMed:17218092, ECO:0000269|PubMed:17346665}.
Tissue SpecificityDetected in embryo 24 to 48 hours after fertilization and in gastrula. {ECO:0000269|PubMed:17997606}.