LMPD Database

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LMP011474

UniProt Annotations

Entry Information
Gene Namenuclear receptor subfamily 2, group F, member 1a
Protein EntryN2F1A_DANRE
UniProt IDQ06725
SpeciesZebrafish
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q06725-1; Sequence=Displayed; Name=2; IsoId=Q06725-2; Sequence=VSP_036606; Note=No experimental confirmation available.; Name=3; IsoId=Q06725-3; Sequence=VSP_036605; Note=No experimental confirmation available.;
FunctionPutative transcription factor that is required in photoreceptor cells precursors during eye development. {ECO:0000269|PubMed:8467797}.
SimilarityBelongs to the nuclear hormone receptor family. NR2 subfamily. {ECO:0000305}.
SimilarityContains 1 nuclear receptor DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00407}.
Subcellular LocationNucleus {ECO:0000255|PROSITE- ProRule:PRU00407}.
Tissue SpecificityFirst expressed in 11-12 hour embryos. In the rostral brain of 13 hour embryos, expressed within the anterior half of the midbrain and the posterior part of the diencephalon. In the presumptive hindbrain, expressed in a segment-like stripe in the anterior region, resembling the presumptive rhombomere units of the hindbrain. Also detected in the intermediate mesoderm, posterior to the first somite. As somitogenesis proceeds, expression extends posteriorly and flanks the 10 most anterior somites. Expression changes extensively both in level and expansion of domains between 13 and 20 hours. In the rostral brain, expression extends to include a major part of the diencephalon and a caudal portion of the telencephalon. Within the hindbrain, strongly expressed in the two most anterior rhombomeres, and a lower but uniform expression is seen to extend throughout rhombomere 7. In 28 hour embryos, higher and more uniform expression is seen in both rostral and hindbrain areas. Also expressed in the retina of the eye. {ECO:0000269|PubMed:17997606, ECO:0000269|PubMed:8467797, ECO:0000269|PubMed:8541212}.