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LMP011476

UniProt Annotations

Entry Information

Gene Name	retinoid x receptor, gamma a
Protein Entry	RXRGA_DANRE
UniProt ID	Q90416
Species	Zebrafish

Comments

Comment type	Description
Developmental Stage	Expressed both maternally and zygotically. {ECO:0000269\|PubMed:16448862, ECO:0000269\|PubMed:17195188, ECO:0000269\|PubMed:7565671}.
Domain	Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
Function	Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for rxrs is 9-cis retinoic acid (By similarity). {ECO:0000250}.
Similarity	Belongs to the nuclear hormone receptor family. NR2 subfamily. {ECO:0000305}.
Similarity	Contains 1 nuclear receptor DNA-binding domain. {ECO:0000255\|PROSITE-ProRule:PRU00407}.
Subcellular Location	Nucleus {ECO:0000255\|PROSITE- ProRule:PRU00407}.
Subunit	Homodimer (By similarity). Heterodimer; with a rar molecule (By similarity). Binds DNA preferentially as a rar/rxr heterodimer (By similarity). Heterodimerizes with rarga. {ECO:0000250}.
Tissue Specificity	Uniformly expressed from the blastula to mid- gastrula stages. In late gastrula stages, there is specific expression in the presumptive hindbrain and spinal cord. At 16 hours post-fertilization (hpf), expressed in the hindbrain from rhombomere 7/8 to the anterior spinal cord; this expression continues until 42 hpf. At 24 hpf, also expressed in the lateral plate mesoderm flanking rhombomere 6 and in the cranial neural crest, but not in the migrating crest. At 26 hpf, also expressed in retina. At 48 hpf, strong retinal expression. {ECO:0000269\|PubMed:17195188, ECO:0000269\|PubMed:7565671}.