LMPD Database

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LMP011477

UniProt Annotations

Entry Information
Gene Nameretinoid x receptor, beta b
Protein EntryQ90417_DANRE
UniProt IDQ90417
SpeciesZebrafish
Comments
Comment typeDescription
Developmental StageExpressed both maternally and zygotically.
DomainComposed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
FunctionReceptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for rxrs is 9-cis retinoic acid (By similarity).
SimilarityBelongs to the nuclear hormone receptor family. NR2 subfamily.
SimilarityContains 1 nuclear receptor DNA-binding domain.
Subcellular LocationNucleus {ECO:0000255|PROSITE- ProRule:PRU00407}.
SubunitHomodimer (By similarity). Heterodimer; with a rar molecule (By similarity). Binds DNA preferentially as a rar/rxr heterodimer (By similarity). Heterodimerizes with rarga.
Tissue SpecificityShows uniform expression from the blastula to mid-gastrula stages. At 12 hours post-fertilization (hpf), expressed ubiquitously but more weakly. At 24 hpf, restricted to the ventral diencephalon, pharangeal endoderm and trunk and tail mesoderm; mesoderm expression is in medial cells of each somite along the dorsoventral axis, forming stripes. At 48 hpf, expressed in forebrain, eye, midbrain and anterior hindbrain.