LMPD Database

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LMP011482

UniProt Annotations

Entry Information
Gene Namethyroid hormone receptor beta
Protein EntryTHB_DANRE
UniProt IDQ9PVE4
SpeciesZebrafish
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9PVE4-1; Sequence=Displayed; Name=2; IsoId=Q9PVE4-2; Sequence=VSP_035801;
CautionIn contrast to PubMed:10687864 and PubMed:11963654, PubMed:17418841 found that triiodothyronine (T3) did not induce expression in the embryo. {ECO:0000305}.
Developmental StageExpressed both maternally and zygotically. Expressed at the 1 cell stage (0 hpf) but disappears by the 2 cell stage. Expressed again from the 16 cell stage onwards. Embryonic expression increases dramatically around the hatching period. High expression then continues until 6 dpf, before declining. {ECO:0000269|PubMed:10687864, ECO:0000269|PubMed:11963654, ECO:0000269|PubMed:17418841}.
DomainComposed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
FunctionNuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for the thyroid gland hormone triiodothyronine (T3). Transactivating activity is ligand-dependent, and is repressed in the absence of T3. {ECO:0000269|PubMed:10687864}.
InductionBy triiodothyronine (T3) and L-thyroxine (T4). {ECO:0000269|PubMed:10687864, ECO:0000269|PubMed:11963654}.
SimilarityBelongs to the nuclear hormone receptor family. NR1 subfamily. {ECO:0000305}.
SimilarityContains 1 nuclear receptor DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00407}.
Subcellular LocationNucleus.
SubunitInteracts (via the ligand-binding domain) with ncoa2. {ECO:0000269|PubMed:18248177}.
Tissue SpecificityWidely expressed in a range of adult tissues including the brain, eye, fin, gill, intestine, liver, swim bladder and ovary. In the eye, expressed in the outer nuclear layer of the retina. {ECO:0000269|PubMed:10687864, ECO:0000269|PubMed:17997606}.