LMPD Database

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LMP011485

UniProt Annotations

Entry Information
Gene Nameretinoic acid receptor, alpha a
Protein EntryQ90271_DANRE
UniProt IDQ90271
SpeciesZebrafish
Comments
Comment typeDescription
Developmental StageNot expressed maternally. First detected at 8 hours post-fertilization (hpf) during gastrulation, with expression being restricted to the posterior epiblast. Expression then increases, reaching a peak at 24 hpf and decreasing from 30- 48 hpf. At 9 hpf, expressed throughout the dorsal epiblast except at the dorsal midline, and ventrally in prospective tail and head regions. At 10-11 hpf, expressed in presumptive hindbrain, posterior neural plate, lateral mesoderm and tail bud. At 12 hpf, strongly expressed in the neural epithelium and tail bud and expressed at low levels elsewhere including the eye. At 24 hpf, restricted to the hindbrain with an anterior border at rhombomere 6-7, to anterior spinal cord and to head mesenchyme just posterior to the otic vesicle. At 48 hpf, hindbrain expression remains and there is diffuse expression in non-neural tissue in the pharyngeal region. {ECO:0000269|PubMed:16455309, ECO:0000269|PubMed:18929555, ECO:0000269|PubMed:7918098}.
DomainComposed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
FunctionReceptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain patterning. {ECO:0000250, ECO:0000269|PubMed:18929555}.
InductionBy retinoic acid in embryos.
SimilarityBelongs to the nuclear hormone receptor family. NR1 subfamily.
SimilarityContains 1 nuclear receptor DNA-binding domain.
Subcellular LocationNucleus {ECO:0000255|PROSITE- ProRule:PRU00407}.
SubunitHeterodimer; with an rxr molecule. Binds DNA preferentially as a rar/rxr heterodimer.
Tissue SpecificityIn the embryo, zygotic expression largely overlaps that of rarab, with high levels in hindbrain, lateral mesoderm and tail bud. In the adult, strong expression in brain and muscle, weaker expression in ovary, liver and digestive tract.