LMPD Database

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LMP011575

UniProt Annotations

Entry Information
Gene Namehydroxysteroid (17-beta) dehydrogenase 12a
Protein EntryDH12A_DANRE
UniProt IDQ6P3L6
SpeciesZebrafish
Comments
Comment typeDescription
Catalytic Activity17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H.
Developmental StageExpressed throughout development. Weakly expressed during early developmental stages from shield to tailbud. {ECO:0000269|PubMed:15026171}.
FunctionCatalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation. {ECO:0000250}.
PathwaySteroid biosynthesis; estrogen biosynthesis.
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.