LMPD Database

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LMP011689

UniProt Annotations

Entry Information
Gene Namedynamin 1-like
Protein EntryDNM1L_DANRE
UniProt IDQ7SXN5
SpeciesZebrafish
Comments
Comment typeDescription
Catalytic ActivityGTP + H(2)O = GDP + phosphate.
FunctionFunctions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane- associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism (By similarity). {ECO:0000250}.
SimilarityBelongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. {ECO:0000305}.
SimilarityContains 1 dynamin-type G (guanine nucleotide-binding) domain. {ECO:0000305}.
SimilarityContains 1 GED domain. {ECO:0000255|PROSITE- ProRule:PRU00720}.
Subcellular LocationCytoplasm, cytosol {ECO:0000250}. Golgi apparatus {ECO:0000250}. Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Mitochondrion outer membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Peroxisome {ECO:0000250}. Membrane, clathrin-coated pit {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}. Note=Mainly cytosolic. Translocates to the mitochondrial outer membrane. Localizes to mitochondria at sites of division. Localizes to mitochondria following necrosis induction. Associated with peroxisomal membranes. May also be associated with endoplasmic reticulum tubules and cytoplasmic vesicles and found to be perinuclear. In some cell types, localizes to the Golgi complex. Binds to phospholipid membranes (By similarity). {ECO:0000250}.
SubunitHomotetramer; dimerizes through the N-terminal GTP-middle region of one molecule binding to the GED domain of another DNM1L molecule. Oligomerizes in a GTP-dependent manner to form membrane- associated tubules with a spiral pattern. Can also oligomerize to form multimeric ring-like structures (By similarity). {ECO:0000250}.