LMPD Database

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LMP011699

UniProt Annotations

Entry Information
Gene Nameadaptor-related protein complex 2, mu 1 subunit, b
Protein EntryAP2MB_DANRE
UniProt IDQ7ZW98
SpeciesZebrafish
Comments
Comment typeDescription
FunctionComponent of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP50 is a subunit of the plasma membrane adaptor. The complex binds polyphosphoinositide-containing lipids (By similarity). {ECO:0000250}.
SimilarityBelongs to the adaptor complexes medium subunit family. {ECO:0000305}.
SimilarityContains 1 MHD (mu homology) domain. {ECO:0000255|PROSITE-ProRule:PRU00404}.
Subcellular LocationCell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma membrane. {ECO:0000250}.
SubunitAdaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit and beta-type subunit), a medium adaptin (mu-type subunit) and a small adaptin (sigma-type subunit). {ECO:0000250}.