LMPD Database

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LMP011773

UniProt Annotations

Entry Information
Gene Namephosphatidylinositol 4-kinase type 2 alpha
Protein EntryP4K2A_DANRE
UniProt IDQ6PE18
SpeciesZebrafish
Comments
Comment typeDescription
Catalytic ActivityATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.
FunctionContributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3) (By similarity). {ECO:0000250}.
SimilarityBelongs to the PI3/PI4-kinase family. Type II PI4K subfamily. {ECO:0000305}.
SimilarityContains 1 PI3K/PI4K domain. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Membrane raft {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Mitochondrion {ECO:0000250}. Endosome {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}.