LMPD Database

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LMP011868

UniProt Annotations

Entry Information
Gene NameCCR4-NOT transcription complex, subunit 1
Protein EntryCNOT1_DANRE
UniProt IDA1A5H6
SpeciesZebrafish
Comments
Comment typeDescription
DomainContains Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, a motif known to be important for the association with nuclear receptors. {ECO:0000250}.
FunctionScaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA- mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors (By similarity). {ECO:0000250}.
SimilarityBelongs to the CNOT1 family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
SubunitComponent of the CCR4-NOT complex. {ECO:0000250}.