LMPD Database

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LMP011990

UniProt Annotations

Entry Information
Gene Namelysophosphatidylcholine acyltransferase 2
Protein EntryPCAT2_DANRE
UniProt IDQ502J0
SpeciesZebrafish
Comments
Comment typeDescription
Catalytic ActivityAcetyl-CoA + 1-alkyl-sn-glycero-3- phosphocholine = CoA + 2-acetyl-1-alkyl-sn-glycero-3- phosphocholine.
Catalytic ActivityAcyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine.
Catalytic ActivityAcyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.
DomainThe HXXXXD motif is essential for acyltransferase activity. {ECO:0000250}.
FunctionPossesses both acyltransferase and acetyltransferase activities. Activity is calcium-dependent. May catalyze the conversion of 1-acyl-sn-glycero-3-phosphocholine to 1,2-diacyl-sn- glycero-3-phosphocholine. May also cataylze the conversion of as well 1-O-alkyl-sn-glycero-3-phosphocholine to 1-O-alkyl-2-acetyl- sn-glycero-3-phosphocholine and 1-O-alkyl-2-acyl-sn-glycero-3- phosphocholine (By similarity). {ECO:0000250}.
PathwayLipid metabolism; phospholipid metabolism.
SimilarityBelongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. {ECO:0000305}.
SimilarityContains 3 EF-hand domains. {ECO:0000255|PROSITE- ProRule:PRU00448}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Lipid droplet {ECO:0000250}.