LMPD Database

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LMP012010

UniProt Annotations

Entry Information
Gene Nameretinoic acid receptor, alpha b
Protein EntryQ7ZTI3_DANRE
UniProt IDQ7ZTI3
SpeciesZebrafish
Comments
Comment typeDescription
Developmental StageExpressed both maternally and zygotically. At 9 hpf, expressed in the dorsal epiblast and prospective tail regions, but absent from the ventral epiblast. At 10 hpf, expressed in presumptive diencephalon and hindbrain, in tissue lateral to the head, the posterior neural plate, tail bud and adjacent mesoderm. At 11-15 hpf, restricted expression along the A-P axis of the neural plate up to the rhobomere 1/2 boundary. During somitogenesis, head and tail expression remains. At 18 hpf, retained expression in the neural tube. At 24 hpf, low levels of ubiquitous expression with stronger expression in eyes, hindbrain and spinal cord; in hindbrain the anterior border is at rhombomeres 3-4. Also expressed in non-neural tissues including pharyngeal endoderm, mesenchyme and tail bud. At 48 hpf, expression is maintained in hindbrain, eyes, diencephalon and the pharyngeal region, and is also observed in forebrain, midbrain and pectoral fin bud. {ECO:0000269|PubMed:16455309, ECO:0000269|PubMed:18929555}.
DomainComposed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
FunctionReceptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain development and, in lateral plate mesoderm, for specification of the pectoral fins.
InductionInduced by retinoic acid.
SimilarityBelongs to the nuclear hormone receptor family. NR1 subfamily.
SimilarityContains 1 nuclear receptor DNA-binding domain.
Subcellular LocationNucleus {ECO:0000255|PROSITE- ProRule:PRU00407}.
SubunitHeterodimer; with an rxr molecule. Binds DNA preferentially as a rar/rxr heterodimer.
Tissue SpecificityIn the embryo, zygotic expression largely overlaps that of raraa, with high levels in hindbrain, lateral plate mesoderm (LPM) and tail bud, but in later stages rarab is expressed more broadly in the brain, pectoral fin bud and pharyngeal arches.