LMPD Database

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LMP012018

UniProt Annotations

Entry Information
Gene Namelysophosphatidylcholine acyltransferase 1
Protein EntryPCAT1_DANRE
UniProt IDQ1LWG4
SpeciesZebrafish
Comments
Comment typeDescription
Catalytic ActivityAcetyl-CoA + 1-alkyl-sn-glycero-3- phosphocholine = CoA + 2-acetyl-1-alkyl-sn-glycero-3- phosphocholine.
Catalytic ActivityAcyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine.
DomainThe di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins. {ECO:0000250}.
DomainThe HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphocholine. {ECO:0000250}.
FunctionPossesses both acyltransferase and acetyltransferase activities. Activity is calcium-independent. Mediates the conversion of 1-acyl-sn-glycero-3-phosphocholine (LPC) into phosphatidylcholine (PC) (By similarity). {ECO:0000250}.
PathwayLipid metabolism; phospholipid metabolism.
SimilarityBelongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. {ECO:0000305}.
SimilarityContains 1 EF-hand domain. {ECO:0000255|PROSITE- ProRule:PRU00448}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Lipid droplet {ECO:0000250}. Note=May adopt a monotopic topology when embedded in the lipid monolayer of the lipid droplet, with both termini exposed to the cytoplasm. {ECO:0000250}.