LMPD Database

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LMP012058

UniProt Annotations

Entry Information
Gene Namevacuolar protein sorting 51 homolog (S. cerevisiae)
Protein EntryVPS51_DANRE
UniProt IDQ155U0
SpeciesZebrafish
Comments
Comment typeDescription
Disruption PhenotypeLarvae are morphologically indistinguishable from wild-type sibling larvae, but their absorption of lipids is severely impaired. {ECO:0000269|PubMed:16581006}.
FunctionMay act as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). Regulator of vesicle recycling and protein sorting. Required for both Golgi structure and vesicular trafficking, and ultimately lipid transport. {ECO:0000269|PubMed:16581006}.
SimilarityBelongs to the VPS51 family. {ECO:0000305}.
Subcellular LocationGolgi apparatus, trans-Golgi network {ECO:0000269|PubMed:16581006}. Note=Also localizes in perinuclear region.
SubunitComponent of the Golgi-associated retrograde protein (GARP) complex. {ECO:0000250}.
Tissue SpecificityUbiquitously expressed in adult. {ECO:0000269|PubMed:16581006}.