LMPD Database

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LMP012115

UniProt Annotations

Entry Information
Gene Namediacylglycerol O-acyltransferase 2
Protein EntryDGAT2_DANRE
UniProt IDQ4V9F0
SpeciesZebrafish
Comments
Comment typeDescription
Catalytic ActivityAcyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.
FunctionEssential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation (By similarity). {ECO:0000250}.
PathwayGlycerolipid metabolism; triacylglycerol biosynthesis.
SimilarityBelongs to the diacylglycerol acyltransferase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.