LMPD Database

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LMP012249

UniProt Annotations

Entry Information
Gene Nameretinoid x receptor, alpha b
Protein EntryQ90415_DANRE
UniProt IDQ90415
SpeciesZebrafish
Comments
Comment typeDescription
Developmental StageExpressed both maternally and zygotically. {ECO:0000269|PubMed:16448862, ECO:0000269|PubMed:17195188, ECO:0000269|PubMed:17997606, ECO:0000269|PubMed:7565671}.
DomainComposed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
FunctionReceptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for this rxr is 9-cis retinoic acid (By similarity).
SimilarityBelongs to the nuclear hormone receptor family. NR2 subfamily.
SimilarityContains 1 nuclear receptor DNA-binding domain.
Subcellular LocationNucleus.
SubunitHomodimer. Heterodimer; with a rar molecule. Binds DNA preferentially as a rar/rxr heterodimer.
Tissue SpecificityUniform expression from the blastula to mid- gastrula stages. At 12 hours post-fertilization (hpf), expressed strongly in the tail and weakly elsewhere. At 24 hpf, weak expression in the forebrain, eyes and pharyngeal endoderm and continued expression in the tail mesoderm. At 48 hpf, anterior expression limited to ventral cells underlying the head, medial expression in the pectoral fin bud mesoderm and continued tail expression. {ECO:0000269|PubMed:16448862, ECO:0000269|PubMed:17195188}.