LMPD Database

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LMP012281

UniProt Annotations

Entry Information
Gene Nameprostaglandin E synthase 2-like
Protein EntryPGES2_DANRE
UniProt IDQ7ZUC7
SpeciesZebrafish
Comments
Comment typeDescription
Catalytic Activity(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15- hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15- dihydroxy-9-oxoprosta-5,13-dienoate. {ECO:0000250|UniProtKB:Q66LN0}.
Enzyme RegulationIsomerase activity is increased by sulfhydril compounds. Dithiothreitol (DTT) is most effective, followed by glutathione (GSH) and 2-mercaptoethanol. {ECO:0000250|UniProtKB:Q66LN0}.
FunctionIsomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2). {ECO:0000250|UniProtKB:Q66LN0}.
PathwayLipid metabolism; prostaglandin biosynthesis. {ECO:0000250|UniProtKB:Q66LN0}.
SimilarityBelongs to the GST superfamily. {ECO:0000305}.
SimilarityContains 1 GST C-terminal domain. {ECO:0000305}.
SimilarityContains 1 GST N-terminal domain. {ECO:0000305}.
Subcellular LocationGolgi apparatus membrane {ECO:0000250|UniProtKB:Q9H7Z7}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9H7Z7}.
SubunitHomodimer. {ECO:0000250|UniProtKB:Q66LN0}.