LMPD Database

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LMP012311

UniProt Annotations

Entry Information
Gene Nameretinoic acid receptor, gamma b
Protein EntryA2T928_DANRE
UniProt IDA2T928
SpeciesZebrafish
Comments
Comment typeDescription
Developmental StageExpressed both maternally and zygotically. Expressed ubiquitously throughout gastrulation. At the tailbud stage, expressed at higher levels in the anterior and tailbud. Also expressed in migrating cranial neural crest cells.
FunctionReceptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain development. {ECO:0000250, ECO:0000269|PubMed:18929555}.
SimilarityBelongs to the nuclear hormone receptor family. NR1 subfamily.
SimilarityContains 1 nuclear receptor DNA-binding domain.
Subcellular LocationNucleus {ECO:0000255|PROSITE- ProRule:PRU00407}.
SubunitHeterodimer; with an rxr molecule. Binds DNA preferentially as a rar/rxr heterodimer.