LMPD Database

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LMP012361

UniProt Annotations

Entry Information
Gene Nameethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)
Protein Entry
UniProt IDQ9C0D9
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=1.8 uM for CDP-ethanolamine ; Vmax=76.3 pmol/min/mg enzyme with CDP-ethanolamine as substrate ;
Catalytic ActivityCDP-ethanolamine + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylethanolamine
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= ; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= ;
FunctionCatalyzes phosphatidylethanolamine biosynthesis from CDP-ethanolamine. It thereby plays a central role in the formation and maintenance of vesicular membranes. Involved in the formation of phosphatidylethanolamine via 'Kennedy' pathway.
PathwayPhospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 3/3.
Sequence CautionSequence=BAB21815.1; Type=Erroneous termination; Positions=387; Note=Translated as Sec.; Evidence= ;
SimilarityBelongs to the CDP-alcohol phosphatidyltransferase class-I family
Subcellular LocationMembrane ; Multi-pass membrane protein
Tissue SpecificityWidely expressed. Abundant in brain, placenta, liver and pancreas, followed by heart, skeletal muscle, lung and kidney. In brain it is strongly expressed in cerebellum, followed by the occipital pole and the frontal lobe