LMPD Database

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LMP012386

UniProt Annotations

Entry Information
Gene Nameacyl-CoA dehydrogenase, C-4 to C-12 straight chain
Protein EntryACADM_RAT
UniProt IDP08503
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityA medium-chain acyl-CoA + electron-transfer flavoprotein = a medium-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein.
CofactorName=FAD; Xref=ChEBI:CHEBI:57692;
FunctionThis enzyme is specific for acyl chain lengths of 4 to 16.
MiscellaneousA number of straight-chain acyl-CoA dehydrogenases of different substrate specificities are present in mammalian tissues.
PathwayLipid metabolism; mitochondrial fatty acid beta- oxidation.
PtmAcetylation at Lys-307 and Lys-311 in proximity of the cofactor-binding sites reduces catalytic activity. These sites are deacetylated by SIRT3 (By similarity)
SimilarityBelongs to the acyl-CoA dehydrogenase family
Subcellular LocationMitochondrion matrix.
SubunitHomotetramer.