LMPD Database

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LMP012392

UniProt Annotations

Entry Information
Gene Nameapolipoprotein C-III
Protein Entry
UniProt ID
SpeciesRat
Comments
Comment typeDescription
FunctionComponent of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. {ECO:0000250|UniProtKB:P02656}.
PtmThe most abundant glycoforms are characterized by an O-linked disaccharide galactose linked to N-acetylgalactosamine (Gal- GalNAc), further modified with up to 3 sialic acid residues. Less abundant glycoforms are characterized by more complex and fucosylated glycan moieties. O-glycosylated on Thr-96 with a core 1 or possibly core 8 glycan. {ECO:0000250|UniProtKB:P02656}.
SimilarityBelongs to the apolipoprotein C3 family. {ECO:0000305}.
Subcellular LocationSecreted {ECO:0000250|UniProtKB:P02656}.
Tissue SpecificitySynthesized predominantly in liver and to a lesser degree in intestine. {ECO:0000269|PubMed:3020028}.