LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP012400

UniProt Annotations

Entry Information
Gene NameNAD(P)H dehydrogenase, quinone 1
Protein EntryNQO1_RAT
UniProt IDP05982
SpeciesRat
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=85 uM for NADH ; KM=39 uM for NADPH ; Note=kcat is 0.075 min(-1) NADH with as substrate. kcat is 0.074 min(-1) with NADPH as substrate ;
Catalytic ActivityNAD(P)H + a quinone = NAD(P)(+) + a hydroquinone. {ECO:0000269|PubMed:1703398, ECO:0000269|PubMed:7862630}.
CautionPubMed:2480957 sequence seems incorrectly to be attributed to a mouse sequence while it really seems to correspond to the rat sequence
CofactorName=FAD; Xref=ChEBI:CHEBI:57692; Evidence= ;
FunctionThe enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. {ECO:0000269|PubMed:1703398, ECO:0000269|PubMed:7862630}.
InductionBy polycyclic hydrocarbons (Governed by the aromatic hydrocarbon-responsive (AH) locus).
MiscellaneousQuinone reductase accepts electrons from both NADH and NADPH with equal efficiency.
MiscellaneousThis protein is inhibited by dicoumarol.
Sequence CautionSequence=AAA41988.1; Type=Erroneous initiation; Evidence= ;
SimilarityBelongs to the NAD(P)H dehydrogenase (quinone) family
Subcellular LocationCytoplasm .
SubunitHomodimer