LMPD Database

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LMP012409

UniProt Annotations

Entry Information
Gene Namehypoxanthine phosphoribosyltransferase 1
Protein EntryHPRT_RAT
UniProt IDP27605
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityGMP + diphosphate = guanine + 5-phospho-alpha- D-ribose 1-diphosphate.
Catalytic ActivityIMP + diphosphate = hypoxanthine + 5-phospho- alpha-D-ribose 1-diphosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= ; Note=Binds 2 magnesium ions per subunit. The magnesium ions are essentially bound to the substrate and have few direct interactions with the protein. ;
FunctionConverts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5- phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity)
PathwayPurine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.
SimilarityBelongs to the purine/pyrimidine phosphoribosyltransferase family
Subcellular LocationCytoplasm.
SubunitHomotetramer