LMPD Database

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LMP012410

UniProt Annotations

Entry Information
Gene Namehydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5
Protein Entry3BHS5_RAT
UniProt IDP27364
SpeciesRat
Comments
Comment typeDescription
Catalytic Activity3-beta-hydroxy-Delta(5)-steroid + NADP(+) = 3- oxo-Delta(5)-steroid + NADPH.
FunctionThe 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD V can only catalyze the conversion of dihydrotestosterone to 5 alpha- androstanediol in the presence of the cofactor NADPH. Exhibits only 3-ketosteroid reductase activity in the presence of NADPH and does not function as an isomerase.
PathwayLipid metabolism; steroid biosynthesis.
SimilarityBelongs to the 3-beta-HSD family
Subcellular LocationEndoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.
Tissue SpecificityExpressed predominantly in male liver.