LMPD Database

LMP012428

Gene Information

Entrez Gene ID	24705
Gene Name	retinoic acid receptor, alpha
Gene Symbol	Rara
Species	Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005737	IDA:RGD	C	cytoplasm
GO:0030425	IDA:RGD	C	dendrite
GO:0043025	IEA:Ensembl	C	neuronal cell body
GO:0043005	IDA:RGD	C	neuron projection
GO:0000790	IEA:Ensembl	C	nuclear chromatin
GO:0005634	IDA:RGD	C	nucleus
GO:0048471	IDA:RGD	C	perinuclear region of cytoplasm
GO:0031490	IEA:Ensembl	F	chromatin DNA binding
GO:0008144	IDA:RGD	F	drug binding
GO:0048027	IDA:RGD	F	mRNA 5'-UTR binding
GO:0035014	IMP:UniProtKB	F	phosphatidylinositol 3-kinase regulator activity
GO:0001972	IEA:Ensembl	F	retinoic acid binding
GO:0003708	IDA:RGD	F	retinoic acid receptor activity
GO:0044323	IEA:Ensembl	F	retinoic acid-responsive element binding
GO:0000977	IEA:Ensembl	F	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003707	IEA:InterPro	F	steroid hormone receptor activity
GO:0003713	IEA:Ensembl	F	transcription coactivator activity
GO:0003714	IEA:Ensembl	F	transcription corepressor activity
GO:0008134	IPI:RGD	F	transcription factor binding
GO:0000900	IDA:RGD	F	translation repressor activity, nucleic acid binding
GO:0008270	IEA:InterPro	F	zinc ion binding
GO:0043277	IEA:Ensembl	P	apoptotic cell clearance
GO:0071391	IEA:Ensembl	P	cellular response to estrogen stimulus
GO:0071222	IEA:Ensembl	P	cellular response to lipopolysaccharide
GO:0071300	IEA:Ensembl	P	cellular response to retinoic acid
GO:0060591	IEA:Ensembl	P	chondroblast differentiation
GO:0031076	IEA:Ensembl	P	embryonic camera-type eye development
GO:0060324	IEA:Ensembl	P	face development
GO:0007565	IEP:RGD	P	female pregnancy
GO:0007281	IEA:Ensembl	P	germ cell development
GO:0002068	IEA:Ensembl	P	glandular epithelial cell development
GO:0003417	IEA:Ensembl	P	growth plate cartilage development
GO:0021766	IEP:RGD	P	hippocampus development
GO:0030520	IEA:Ensembl	P	intracellular estrogen receptor signaling pathway
GO:0060173	IEA:Ensembl	P	limb development
GO:0001889	IEP:RGD	P	liver development
GO:0008584	IDA:RGD	P	male gonad development
GO:0035264	IEA:Ensembl	P	multicellular organism growth
GO:0043066	IEA:Ensembl	P	negative regulation of apoptotic process
GO:0061037	IEA:Ensembl	P	negative regulation of cartilage development
GO:0008285	IDA:RGD	P	negative regulation of cell proliferation
GO:0030853	IEA:Ensembl	P	negative regulation of granulocyte differentiation
GO:0032689	IEA:Ensembl	P	negative regulation of interferon-gamma production
GO:0000122	IEA:Ensembl	P	negative regulation of transcription from RNA polymerase II promoter
GO:0017148	IDA:RGD	P	negative regulation of translation
GO:0045947	IEA:Ensembl	P	negative regulation of translational initiation
GO:0032720	IEA:Ensembl	P	negative regulation of tumor necrosis factor production
GO:0001843	IEA:Ensembl	P	neural tube closure
GO:0003148	IEA:Ensembl	P	outflow tract septum morphogenesis
GO:0051099	IEA:Ensembl	P	positive regulation of binding
GO:0045787	IEA:Ensembl	P	positive regulation of cell cycle
GO:0008284	IEA:Ensembl	P	positive regulation of cell proliferation
GO:0070374	IMP:UniProtKB	P	positive regulation of ERK1 and ERK2 cascade
GO:0032736	IEA:Ensembl	P	positive regulation of interleukin-13 production
GO:0032753	IEA:Ensembl	P	positive regulation of interleukin-4 production
GO:0032754	IEA:Ensembl	P	positive regulation of interleukin-5 production
GO:0045666	IDA:RGD	P	positive regulation of neuron differentiation
GO:0014068	IMP:UniProtKB	P	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0051897	IMP:UniProtKB	P	positive regulation of protein kinase B signaling
GO:0045630	IEA:Ensembl	P	positive regulation of T-helper 2 cell differentiation
GO:0045944	IEA:Ensembl	P	positive regulation of transcription from RNA polymerase II promoter
GO:0030850	IEP:RGD	P	prostate gland development
GO:0006468	IEA:Ensembl	P	protein phosphorylation
GO:0042981	IDA:RGD	P	regulation of apoptotic process
GO:0031641	IDA:RGD	P	regulation of myelination
GO:0043551	IMP:GOC	P	regulation of phosphatidylinositol 3-kinase activity
GO:0048167	IDA:RGD	P	regulation of synaptic plasticity
GO:0034097	IEP:RGD	P	response to cytokine
GO:0032355	IEP:RGD	P	response to estradiol
GO:0045471	IDA:RGD	P	response to ethanol
GO:0033189	IEP:RGD	P	response to vitamin A
GO:0048384	IDA:RGD	P	retinoic acid receptor signaling pathway
GO:0060010	IEA:Ensembl	P	Sertoli cell fate commitment
GO:0007283	IEA:Ensembl	P	spermatogenesis
GO:0060534	IEA:Ensembl	P	trachea cartilage development
GO:0001657	IEA:Ensembl	P	ureteric bud development
GO:0055012	IEA:Ensembl	P	ventricular cardiac muscle cell differentiation

KEGG Pathway Links

KEGG Pathway ID	Description
ko05221	Acute myeloid leukemia
rno05221	Acute myeloid leukemia
rno05200	Pathways in cancer
ko05202	Transcriptional misregulation in cancer
rno05202	Transcriptional misregulation in cancer

REACTOME Pathway Links

REACTOME Pathway ID	Description
5953330	Gene Expression
5953833	Generic Transcription Pathway
5954147	Nuclear Receptor transcription pathway