LMPD Database

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LMP012434

UniProt Annotations

Entry Information
Gene Namesex hormone binding globulin
Protein EntrySHBG_RAT
UniProt IDP08689
SpeciesRat
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=1; IsoId=P08689-1; Sequence=Displayed; Name=2; IsoId=P08689-2; Sequence=VSP_006093, VSP_006094; Note=Incomplete sequence.;
Developmental StageIn the fetal liver, expressed from day 14 to day 17 after conception.
FunctionFunctions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration (By similarity)
MiscellaneousA putative trans-splicing which involves HDC and SHBG gene regions produces a fusion protein expressed in fetal liver.
SimilarityContains 2 laminin G-like domains
Subcellular LocationSecreted. Note=In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis.
SubunitHomodimer.
Tissue SpecificityIsoform 2 is only expressed in the liver.