LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP012439

UniProt Annotations

Entry Information
Gene Namesynaptotagmin II
Protein EntrySYT2_RAT
UniProt IDP29101
SpeciesRat
Comments
Comment typeDescription
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence= ; Note=Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains. ;
DomainThe first C2 domain mediates Ca(2+)-dependent phospholipid binding.
DomainThe second C2 domain mediates interaction with Stonin 2
FunctionMay have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
InteractionP10844:botB (xeno); NbExp=3; IntAct=EBI-458017, EBI-7661991; Q9H4A3:WNK1 (xeno); NbExp=2; IntAct=EBI-458017, EBI-457907; Q9JIH7:Wnk1; NbExp=9; IntAct=EBI-458017, EBI-457953;
SimilarityBelongs to the synaptotagmin family
SimilarityContains 2 C2 domains. {ECO:0000255|PROSITE- ProRule:PRU00041}.
Subcellular LocationCytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass membrane protein. Cytoplasm. Note=Synaptic vesicles and chromaffin granules.
SubunitHomotetramer (Probable). Interacts with SCAMP5 and stonin 2 (By similarity)
Tissue SpecificityPredominantly expressed in phylogenetically older brain regions such as the spinal cord, brain stem and cerebellum.