LMPD Database

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LMP012443

UniProt Annotations

Entry Information
Gene NameUDP glucuronosyltransferase 1 family, polypeptide A1
Protein EntryUD11_RAT
UniProt IDQ64550
SpeciesRat
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=1; Comment=A number of isoforms are produced. The different isozymes have a different N-terminal domain and a common C-terminal domain of 245 residues.; Name=1; IsoId=Q64550-1; Sequence=Displayed;
Catalytic ActivityUDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
FunctionUDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Glucuronates opioids and bilirubin.
InductionOverexpressed of two- to threefold upon clofibrate and dexamethasone administration
SimilarityBelongs to the UDP-glycosyltransferase family
Subcellular LocationMicrosome. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein .
SubunitPart of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.