LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP012448

UniProt Annotations

Entry Information
Gene Namesulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
Protein EntryST2A1_RAT
UniProt IDP15709
SpeciesRat
Comments
Comment typeDescription
Catalytic Activity3'-phosphoadenylyl sulfate + glycolithocholate = adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate.
Catalytic Activity3'-phosphoadenylyl sulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate.
Developmental StageThere is a marked sex difference (female >> male) in the expressed level of mRNA for this protein.
FunctionSulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze sulfonation of hydroxysteroids and xenobiotics. Bioactivation of carcinogenic polycyclic arylmethanols.
InductionInduced by estrogens and suppressed by androgens. Expression is under the influence of pituitary growth hormone and thyroid hormone.
SimilarityBelongs to the sulfotransferase 1 family
Subcellular LocationCytoplasm.