LMPD Database

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LMP012449

UniProt Annotations

Entry Information
Gene Namephospholipase A2, group XVI
Protein EntryHRSL3_RAT
UniProt IDP53817
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityPhosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate.
Catalytic ActivityPhosphatidylcholine + H(2)O = 2- acylglycerophosphocholine + a carboxylate.
FunctionExhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphotidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Specifically catalyzes the release of fatty acids from phospholipids in adipose tissue. N- and O-acylation activity is hardly detectable. Also has weak lysophospholipase activity (By similarity)
InductionInduced during preadipocyte differentiation into adipocytes
SimilarityBelongs to the H-rev107 family
Subcellular LocationCytoplasm . Cytoplasm, perinuclear region . Membrane ; Single-pass membrane protein .
SubunitInteracts with PPP2R1A; this interaction might decrease PP2A activity
Tissue SpecificitySpecifically expressed in H-ras resistant fibroblasts. {ECO:0000269|PubMed:18614531, ECO:0000269|PubMed:8290259}.