LMPD Database

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LMP012457

UniProt Annotations

Entry Information
Gene Namephospholipase C, beta 4
Protein EntryPLCB4_RAT
UniProt IDQ9QW07
SpeciesRat
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=A; IsoId=Q9QW07-1; Sequence=Displayed; Name=B; IsoId=Q9QW07-2; Sequence=VSP_004724, VSP_004725; Name=C; IsoId=Q9QW07-3; Sequence=VSP_004726;
Catalytic Activity1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108;
FunctionThe production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction.
SimilarityContains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}.
SimilarityContains 1 PI-PLC X-box domain. {ECO:0000255|PROSITE- ProRule:PRU00270}.
SimilarityContains 1 PI-PLC Y-box domain. {ECO:0000255|PROSITE- ProRule:PRU00271}.
Tissue SpecificityPreferentially expressed in the retina.