LMPD Database

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LMP012466

UniProt Annotations

Entry Information
Gene Nameapolipoprotein A-IV
Protein EntryAPOA4_RAT
UniProt IDP02651
SpeciesRat
Comments
Comment typeDescription
DomainNine of the thirteen 22-amino acid tandem repeats (each 22-mer is actually a tandem array of two, A and B, related 11- mers) occurring in this sequence are predicted to be highly alpha- helical, and many of these helices are amphipathic. They may therefore serve as lipid-binding domains with lecithin:cholesterol acyltransferase (LCAT) activating abilities.
FunctionMay have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.
SimilarityBelongs to the apolipoprotein A1/A4/E family
Subcellular LocationSecreted.
SubunitHomodimer
Tissue SpecificitySecreted in plasma.