LMPD Database

LMP012467

Gene Information

Entrez Gene ID	25081
Gene Name	apolipoprotein A-I
Gene Symbol	Apoa1
Species	Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0072562	IEA:Ensembl	C	blood microparticle
GO:0009986	IDA:RGD	C	cell surface
GO:0034365	IDA:RGD	C	discoidal high-density lipoprotein particle
GO:0030139	IEA:Ensembl	C	endocytic vesicle
GO:0005615	IDA:RGD	C	extracellular space
GO:0070062	IEA:Ensembl	C	extracellular vesicular exosome
GO:0005634	IDA:RGD	C	nucleus
GO:0034366	IEA:Ensembl	C	spherical high-density lipoprotein particle
GO:0034361	IEA:Ensembl	C	very-low-density lipoprotein particle
GO:0001540	IEA:Ensembl	F	beta-amyloid binding
GO:0015485	IEA:Ensembl	F	cholesterol binding
GO:0017127	IDA:RGD	F	cholesterol transporter activity
GO:0008035	IEA:Ensembl	F	high-density lipoprotein particle binding
GO:0055102	IDA:RGD	F	lipase inhibitor activity
GO:0060228	IEA:Ensembl	F	phosphatidylcholine-sterol O-acyltransferase activator activity
GO:0005543	IEA:Ensembl	F	phospholipid binding
GO:0005548	IDA:RGD	F	phospholipid transporter activity
GO:0030325	IEA:Ensembl	P	adrenal gland development
GO:0043534	IEA:Ensembl	P	blood vessel endothelial cell migration
GO:0006695	IEA:Ensembl	P	cholesterol biosynthetic process
GO:0033344	IEA:Ensembl	P	cholesterol efflux
GO:0042632	IEA:Ensembl	P	cholesterol homeostasis
GO:0070508	IEA:Ensembl	P	cholesterol import
GO:0030301	IDA:RGD	P	cholesterol transport
GO:0001935	IEA:Ensembl	P	endothelial cell proliferation
GO:0008211	IEA:Ensembl	P	glucocorticoid metabolic process
GO:0007186	IEA:Ensembl	P	G-protein coupled receptor signaling pathway
GO:0034380	IEA:Ensembl	P	high-density lipoprotein particle assembly
GO:0019915	IEA:Ensembl	P	lipid storage
GO:0042158	IEA:Ensembl	P	lipoprotein biosynthetic process
GO:0060354	IEA:Ensembl	P	negative regulation of cell adhesion molecule production
GO:0002740	IEA:Ensembl	P	negative regulation of cytokine secretion involved in immune response
GO:0034115	IEA:Ensembl	P	negative regulation of heterotypic cell-cell adhesion
GO:0050728	IEA:Ensembl	P	negative regulation of inflammatory response
GO:0050713	IEA:Ensembl	P	negative regulation of interleukin-1 beta secretion
GO:0060192	IDA:RGD	P	negative regulation of lipase activity
GO:0010804	IEA:Ensembl	P	negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0010903	IEA:Ensembl	P	negative regulation of very-low-density lipoprotein particle remodeling
GO:0031100	IDA:RGD	P	organ regeneration
GO:0018206	IEA:Ensembl	P	peptidyl-methionine modification
GO:0014012	IEP:RGD	P	peripheral nervous system axon regeneration
GO:0006656	IEA:Ensembl	P	phosphatidylcholine biosynthetic process
GO:0033700	IEA:Ensembl	P	phospholipid efflux
GO:0055091	IEA:Ensembl	P	phospholipid homeostasis
GO:0015914	IDA:RGD	P	phospholipid transport
GO:0010873	IEA:Ensembl	P	positive regulation of cholesterol esterification
GO:0051345	IEA:Ensembl	P	positive regulation of hydrolase activity
GO:0051347	IEA:Ensembl	P	positive regulation of transferase activity
GO:0018158	IEA:Ensembl	P	protein oxidation
GO:0050821	IEA:Ensembl	P	protein stabilization
GO:0032489	IEA:Ensembl	P	regulation of Cdc42 protein signal transduction
GO:0030300	IEA:Ensembl	P	regulation of intestinal cholesterol absorption
GO:0001932	IEA:Ensembl	P	regulation of protein phosphorylation
GO:0042493	IEP:RGD	P	response to drug
GO:0043627	IEP:RGD	P	response to estrogen
GO:0007584	IEP:RGD	P	response to nutrient
GO:0043691	IEA:Ensembl	P	reverse cholesterol transport
GO:0070328	IEA:Ensembl	P	triglyceride homeostasis

KEGG Pathway Links

KEGG Pathway ID	Description
ko05143	African trypanosomiasis
rno05143	African trypanosomiasis
ko04975	Fat digestion and absorption
rno04975	Fat digestion and absorption
ko03320	PPAR signaling pathway
rno03320	PPAR signaling pathway
ko04977	Vitamin digestion and absorption
rno04977	Vitamin digestion and absorption

REACTOME Pathway Links

REACTOME Pathway ID	Description
5954098	ABCA transporters in lipid homeostasis
5954099	ABC-family proteins mediated transport
5954397	Amyloids
5954562	Binding and Uptake of Ligands by Scavenger Receptors
5953879	Chylomicron-mediated lipid transport
5953253	Disease
5953382	Diseases associated with visual transduction
5953288	Fatty acid, triacylglycerol, and ketone body metabolism
5954088	HDL-mediated lipid transport
5953645	Hemostasis
5953754	Lipid digestion, mobilization, and transport
5953836	Lipoprotein metabolism
5953250	Metabolism
5953289	Metabolism of lipids and lipoproteins
5953644	Platelet activation, signaling and aggregation
5954102	Platelet degranulation
5954333	PPARA activates gene expression
5954222	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
5953646	Response to elevated platelet cytosolic Ca2+
5954392	Retinoid metabolism and transport
5954564	Scavenging by Class A Receptors
5954565	Scavenging by Class B Receptors
5954561	Scavenging of heme from plasma
5953381	Signal Transduction
5953265	Transmembrane transport of small molecules
5953380	Visual phototransduction