LMPD Database

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LMP012469

UniProt Annotations

Entry Information
Gene Namephospholipase D1
Protein EntryPLD1_RAT
UniProt IDP70496
SpeciesRat
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=PLD1A; IsoId=P70496-1; Sequence=Displayed; Name=PLD1B; IsoId=P70496-2; Sequence=VSP_005024; Name=PLD1C; IsoId=P70496-3; Sequence=VSP_005025, VSP_005026;
Catalytic ActivityA phosphatidylcholine + H(2)O = choline + a phosphatidate.
Enzyme RegulationStimulated by phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate, activated by the phosphokinase C-alpha, by the ADP-ribosylation factor-1 (ARF-1), and to a lesser extent by GTP-binding proteins: RHO A, RAC-1 and CDC42
FunctionImplicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity)
PtmIt is uncertain whether palmitoylation is on Cys-240 and/or Cys-241. Palmitoylation is required prior to phosphorylation
PtmPhosphorylated on serine and threonine residues
SimilarityBelongs to the phospholipase D family
SimilarityContains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
SimilarityContains 1 PX (phox homology) domain
SimilarityContains 2 PLD phosphodiesterase domains
Subcellular LocationCytoplasm, perinuclear region . Endoplasmic reticulum membrane ; Lipid-anchor {ECO:0000250}. Golgi apparatus membrane ; Lipid- anchor {ECO:0000250}. Late endosome membrane ; Lipid- anchor . Note=Membrane-associated.
SubunitInteracts with PIP5K1B