LMPD Database

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LMP012472

UniProt Annotations

Entry Information
Gene Namehydroxysteroid 11-beta dehydrogenase 1
Protein EntryDHI1_RAT
UniProt IDP16232
SpeciesRat
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative promoter usage; Named isoforms=2; Name=11-HSD1A; IsoId=P16232-1; Sequence=Displayed; Name=11-HSD1B; IsoId=P16232-2; Sequence=VSP_012616; Note=Kidney-specific.;
Catalytic ActivityAn 11-beta-hydroxysteroid + NADP(+) = an 11- oxosteroid + NADPH.
Developmental StageExpression of both isoforms is found in 1 week-old rats. Expression increases exponentially up to 4 weeks but after this time there is no further increase up to 16 weeks.
FunctionCatalyzes reversibly the conversion of corticosterone to 11-dehydrocorticosterone.
PtmGlycosylated.
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family
Subcellular LocationEndoplasmic reticulum membrane; Single-pass type II membrane protein.
SubunitHomodimer
Tissue SpecificityLiver, kidney, testis and placenta.