LMPD Database

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LMP012473

UniProt Annotations

Entry Information
Gene Namehydroxysteroid 11-beta dehydrogenase 2
Protein EntryDHI2_RAT
UniProt IDP50233
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityAn 11-beta-hydroxysteroid + NAD(+) = an 11- oxosteroid + NADH.
FunctionCatalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family
Subcellular LocationMicrosome. Endoplasmic reticulum .
SubunitInteracts with ligand-free cytoplasmic NR3C2
Tissue SpecificityHighly expressed in kidney, adrenal gland and distal colon. Detected at much lower levels in lung.