LMPD Database

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LMP012479

UniProt Annotations

Entry Information
Gene NameST6 beta-galactosamide alpha-2,6-sialyltranferase 1
Protein EntrySIAT1_RAT
UniProt IDP13721
SpeciesRat
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=RLA; IsoId=P13721-1; Sequence=Displayed; Name=RKA; IsoId=P13721-2; Sequence=VSP_001782; Name=RKB; IsoId=P13721-3; Sequence=VSP_001783;
Catalytic ActivityCMP-N-acetylneuraminate + beta-D-galactosyl- 1,4-N-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl- 2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
FunctionTransfers sialic acid from CMP-sialic acid to galactose- containing acceptor substrates
PathwayProtein modification; protein glycosylation.
PtmThe soluble form derives from the membrane form by proteolytic processing.
SimilarityBelongs to the glycosyltransferase 29 family
Subcellular LocationGolgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane- bound form in trans cisternae of Golgi. Secreted into the body fluid.
Tissue SpecificityStrongly expressed in liver, spleen, lung, kidney and submaxillary gland and weakly in heart and brain.