LMPD Database

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LMP012487

Gene Information

Entrez Gene ID25267
Gene Nameplatelet derived growth factor receptor, alpha polypeptide
Gene SymbolPdgfra
SpeciesRattus norvegicus
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005887 ISS:UniProtKBCintegral component of plasma membrane
GO:0005634 IDA:UniProtKBCnucleus
GO:0005886 IDA:UniProtKBCplasma membrane
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0043548 IPI:RGDFphosphatidylinositol 3-kinase binding
GO:0005018 IDA:RGDFplatelet-derived growth factor alpha-receptor activity
GO:0046983 NAS:RGDFprotein dimerization activity
GO:0042803 ISS:UniProtKBFprotein homodimerization activity
GO:0005021 ISS:UniProtKBFvascular endothelial growth factor-activated receptor activity
GO:0055003 ISS:UniProtKBPcardiac myofibril assembly
GO:0060326 ISS:UniProtKBPcell chemotaxis
GO:0048701 ISS:UniProtKBPembryonic cranial skeleton morphogenesis
GO:0048557 ISS:UniProtKBPembryonic digestive tract morphogenesis
GO:0048704 ISS:UniProtKBPembryonic skeletal system morphogenesis
GO:0042063 IEP:RGDPgliogenesis
GO:0048839 IEP:RGDPinner ear development
GO:0001553 ISS:UniProtKBPluteinization
GO:0072277 ISS:UniProtKBPmetanephric glomerular capillary formation
GO:0010544 ISS:UniProtKBPnegative regulation of platelet activation
GO:0018108 ISS:UniProtKBPpeptidyl-tyrosine phosphorylation
GO:0048015 ISS:UniProtKBPphosphatidylinositol-mediated signaling
GO:0070527 ISS:UniProtKBPplatelet aggregation
GO:0035790 IDA:GOCPplatelet-derived growth factor receptor-alpha signaling pathway
GO:0048008 ISS:UniProtKBPplatelet-derived growth factor receptor signaling pathway
GO:0030335 ISS:UniProtKBPpositive regulation of cell migration
GO:0008284 IMP:RGDPpositive regulation of cell proliferation
GO:0007204 ISS:UniProtKBPpositive regulation of cytosolic calcium ion concentration
GO:0045740 ISS:UniProtKBPpositive regulation of DNA replication
GO:0070374 ISS:UniProtKBPpositive regulation of ERK1 and ERK2 cascade
GO:0048146 ISS:UniProtKBPpositive regulation of fibroblast proliferation
GO:0043552 ISS:UniProtKBPpositive regulation of phosphatidylinositol 3-kinase activity
GO:0046777 ISS:UniProtKBPprotein autophosphorylation
GO:2000739 ISS:UniProtKBPregulation of mesenchymal stem cell differentiation
GO:0034097 IEP:RGDPresponse to cytokine
GO:0032355 IEP:RGDPresponse to estradiol
GO:0043627 IEP:RGDPresponse to estrogen
GO:0009725 IEP:RGDPresponse to hormone
GO:0055093 IEP:RGDPresponse to hyperoxia
GO:0010035 IEP:RGDPresponse to inorganic substance
GO:0010033 IEP:RGDPresponse to organic substance
GO:0061298 ISS:UniProtKBPretina vasculature development in camera-type eye
GO:0038084 ISS:GOCPvascular endothelial growth factor signaling pathway
GO:0042060 IEP:RGDPwound healing
KEGG Pathway Links
KEGG Pathway IDDescription
ko04020Calcium signaling pathway
rno04020Calcium signaling pathway
ko04060Cytokine-cytokine receptor interaction
rno04060Cytokine-cytokine receptor interaction
ko04144Endocytosis
rno04144Endocytosis
ko04510Focal adhesion
rno04510Focal adhesion
ko04540Gap junction
rno04540Gap junction
ko05214Glioma
rno05214Glioma
ko05166HTLV-I infection
rno05166HTLV-I infection
ko04010MAPK signaling pathway
rno04010MAPK signaling pathway
ko05218Melanoma
rno05218Melanoma
ko05206MicroRNAs in cancer
rno05206MicroRNAs in cancer
rno05200Pathways in cancer
ko04151PI3K-Akt signaling pathway
rno04151PI3K-Akt signaling pathway
ko05215Prostate cancer
rno05215Prostate cancer
ko04015Rap1 signaling pathway
rno04015Rap1 signaling pathway
rno04014Ras signaling pathway
ko04810Regulation of actin cytoskeleton
rno04810Regulation of actin cytoskeleton
REACTOME Pathway Links
REACTOME Pathway IDDescription
5953415Adaptive Immune System
5954570Constitutive PI3K/AKT Signaling in Cancer
5953408DAP12 interactions
5953407DAP12 signaling
5953253Disease
5953994Downstream signaling events of B Cell Receptor (BCR)
5953399Downstream signaling of activated FGFR
5953396Downstream signal transduction
5953417Fc epsilon receptor (FCERI) signaling
5953884GAB1 signalosome
5953410Immune System
5953409Innate Immune System
5953394NGF signalling via TRKA from the plasma membrane
5953989PI3K/AKT activation
5953997PI3K/AKT Signaling in Cancer
5953885PI-3K cascade
5953996PI3K events in ERBB2 signaling
5953995PI3K events in ERBB4 signaling
5953993PIP3 activates AKT signaling
5953998Role of LAT2/NTAL/LAB on calcium mobilization
5953403Signaling by EGFR
5953404Signaling by EGFR in Cancer
5953406Signaling by ERBB2
5953540Signaling by ERBB4
5953400Signaling by FGFR
5953401Signaling by FGFR in disease
5953397Signaling by PDGF
5953541Signaling by SCF-KIT
5953414Signaling by the B Cell Receptor (BCR)
5953395Signalling by NGF
5953381Signal Transduction