LMPD Database

LMP012488

Gene Information

Entrez Gene ID	25271
Gene Name	retinoid X receptor alpha
Gene Symbol	Rxra
Species	Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0000790	IEA:Ensembl	C	nuclear chromatin
GO:0004886	IEA:Ensembl	F	9-cis retinoic acid receptor activity
GO:0031490	IEA:Ensembl	F	chromatin DNA binding
GO:0044323	IEA:Ensembl	F	retinoic acid-responsive element binding
GO:0000977	IEA:Ensembl	F	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003707	IEA:InterPro	F	steroid hormone receptor activity
GO:0070644	IEA:Ensembl	F	vitamin D response element binding
GO:0008270	IEA:InterPro	F	zinc ion binding
GO:0043010	IEA:Ensembl	P	camera-type eye development
GO:0060038	IEA:Ensembl	P	cardiac muscle cell proliferation
GO:0007566	IEA:Ensembl	P	embryo implantation
GO:0001701	IEA:Ensembl	P	in utero embryonic development
GO:0001893	IEA:Ensembl	P	maternal placenta development
GO:0019048	IEA:Ensembl	P	modulation by virus of host morphology or physiology
GO:0000122	IEA:Ensembl	P	negative regulation of transcription from RNA polymerase II promoter
GO:0035357	IEA:Ensembl	P	peroxisome proliferator activated receptor signaling pathway
GO:0045944	IEA:Ensembl	P	positive regulation of transcription from RNA polymerase II promoter
GO:0051289	IEA:Ensembl	P	protein homotetramerization
GO:0060687	IEA:Ensembl	P	regulation of branching involved in prostate gland morphogenesis
GO:0032526	IEA:Ensembl	P	response to retinoic acid
GO:0060528	IEA:Ensembl	P	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
GO:0055012	IEA:Ensembl	P	ventricular cardiac muscle cell differentiation
GO:0055010	IEA:Ensembl	P	ventricular cardiac muscle tissue morphogenesis

KEGG Pathway Links

KEGG Pathway ID	Description
ko04920	Adipocytokine signaling pathway
rno04920	Adipocytokine signaling pathway
ko04976	Bile secretion
rno04976	Bile secretion
ko05160	Hepatitis C
rno05160	Hepatitis C
ko04932	Non-alcoholic fatty liver disease (NAFLD)
rno04932	Non-alcoholic fatty liver disease (NAFLD)
ko05223	Non-small cell lung cancer
rno05223	Non-small cell lung cancer
rno05200	Pathways in cancer
ko04151	PI3K-Akt signaling pathway
rno04151	PI3K-Akt signaling pathway
ko03320	PPAR signaling pathway
rno03320	PPAR signaling pathway
ko05222	Small cell lung cancer
rno05222	Small cell lung cancer
ko05216	Thyroid cancer
rno05216	Thyroid cancer
rno04919	Thyroid hormone signaling pathway
ko05202	Transcriptional misregulation in cancer
rno05202	Transcriptional misregulation in cancer

REACTOME Pathway Links

REACTOME Pathway ID	Description
5954496	Activation of gene expression by SREBF (SREBP)
5953720	Bile acid and bile salt metabolism
5953258	Biological oxidations
5954332	BMAL1:CLOCK,NPAS2 activates circadian gene expression
5954223	Circadian Clock
5953485	Cytochrome P450 - arranged by substrate type
5953533	Developmental Biology
5953932	Endogenous sterols
5953288	Fatty acid, triacylglycerol, and ketone body metabolism
5953330	Gene Expression
5953833	Generic Transcription Pathway
5953467	Import of palmitoyl-CoA into the mitochondrial matrix
5953250	Metabolism
5953289	Metabolism of lipids and lipoproteins
5953600	Mitochondrial biogenesis
5954147	Nuclear Receptor transcription pathway
5953601	Organelle biogenesis and maintenance
5953326	Phase 1 - Functionalization of compounds
5954333	PPARA activates gene expression
5953268	Pyruvate metabolism
5953269	Pyruvate metabolism and Citric Acid (TCA) cycle
5953719	Recycling of bile acids and salts
5954497	Regulation of cholesterol biosynthesis by SREBP (SREBF)
5954222	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
5954047	Regulation of pyruvate dehydrogenase (PDH) complex
5954224	REV-ERBA represses gene expression
5954225	RORA activates circadian gene expression
5953930	Synthesis of bile acids and bile salts
5953929	Synthesis of bile acids and bile salts via 27-hydroxycholesterol
5953931	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
5953270	The citric acid (TCA) cycle and respiratory electron transport
5953599	Transcriptional activation of mitochondrial biogenesis
5954166	Transcriptional regulation of white adipocyte differentiation
5954528	YAP1- and WWTR1 (TAZ)-stimulated gene expression