LMPD Database

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LMP012495

UniProt Annotations

Entry Information
Gene Namearachidonate 5-lipoxygenase
Protein EntryLOX5_RAT
UniProt IDP12527
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityArachidonate + O(2) = leukotriene A(4) + H(2)O.
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence= ; Note=Binds 2 calcium ions per subunit. ;
CofactorName=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence= ; Note=Binds 1 Fe cation per subunit. {ECO:0000255|PROSITE- ProRule:PRU00726};
FunctionCatalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.
PathwayLipid metabolism; leukotriene A4 biosynthesis.
PtmSerine phosphorylation by MAPKAPK2 is stimulated by arachidonic acid. Phosphorylation on Ser-523 by PKA has an inhibitory effect. Phosphorylation on Ser-271 prevents export from the nucleus (By similarity)
Sequence CautionSequence=AAA41538.1; Type=Frameshift; Positions=667; Evidence= ;
SimilarityBelongs to the lipoxygenase family
SimilarityContains 1 lipoxygenase domain. {ECO:0000255|PROSITE- ProRule:PRU00726}.
SimilarityContains 1 PLAT domain. {ECO:0000255|PROSITE- ProRule:PRU00152}.
Subcellular LocationCytoplasm. Nucleus matrix. Nucleus membrane; Peripheral membrane protein. Note=Shuttles between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser-271. Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association.
SubunitInteracts with ALOX5AP and LTC4S. Interacts with COTL1, the interaction is required for stability and efficient catalytic activity (By similarity)