LMPD Database

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LMP012500

UniProt Annotations

Entry Information
Gene Namelipase, hormone sensitive
Protein EntryLIPS_RAT
UniProt IDP15304
SpeciesRat
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Testicular; IsoId=P15304-1; Sequence=Displayed; Name=2; IsoId=P15304-2; Sequence=VSP_017117;
Catalytic ActivityDiacylglycerol + H(2)O = monoacylglycerol + a carboxylate.
Catalytic ActivityMonoacylglycerol + H(2)O = glycerol + a carboxylate.
Catalytic ActivityTriacylglycerol + H(2)O = diacylglycerol + a carboxylate.
Enzyme RegulationRapidly activated by cAMP-dependent phosphorylation under the influence of catecholamines. Dephosphorylation and inactivation are controlled by insulin.
FunctionIn adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.
PathwayGlycerolipid metabolism; triacylglycerol degradation.
PtmPhosphorylation by AMPK may block translocation to lipid droplets
SimilarityBelongs to the 'GDXG' lipolytic enzyme family
Subcellular LocationCell membrane . Membrane, caveola {ECO:0000250}. Cytoplasm, cytosol . Note=Found in the high-density caveolae. Translocates to the cytoplasm from the caveolae upon insulin stimulation
SubunitInteracts with PTRF in the adipocyte cytoplasm (By similarity). Interacts with PLIN5. {ECO:0000250, ECO:0000269|PubMed:24303154}.