LMPD Database

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LMP012503

UniProt Annotations

Entry Information
Gene Nameacyl-CoA dehydrogenase, very long chain
Protein EntryACADV_RAT
UniProt IDP45953
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityA very-long-chain acyl-CoA + electron-transfer flavoprotein = a very-long-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein.
CofactorName=FAD; Xref=ChEBI:CHEBI:57692;
FunctionActive toward esters of long-chain and very long chain fatty acids such as palmitoyl-CoA, mysritoyl-CoA and stearoyl-CoA. Can accommodate substrate acyl chain lengths as long as 24 carbons, but shows little activity for substrates of less than 12 carbons.
MiscellaneousA number of straight-chain acyl-CoA dehydrogenases of different substrate specificities are present in mammalian tissues.
PathwayLipid metabolism; mitochondrial fatty acid beta- oxidation.
PtmS-nitrosylation at Cys-237 in liver improves catalytic efficiency
SimilarityBelongs to the acyl-CoA dehydrogenase family
Subcellular LocationMitochondrion inner membrane.
SubunitHomodimer.