LMPD Database

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LMP012514

UniProt Annotations

Entry Information
Gene Namephosphatidylethanolamine N-methyltransferase
Protein EntryPEMT_RAT
UniProt IDQ08388
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityS-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine. {ECO:0000255|PROSITE- ProRule:PRU00931}.
Catalytic ActivityS-adenosyl-L-methionine + phosphatidyl-N- dimethylethanolamine = S-adenosyl-L-homocysteine + phosphatidylcholine
Catalytic ActivityS-adenosyl-L-methionine + phosphatidyl-N- methylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N- dimethylethanolamine
FunctionCatalyzes three sequential methylation reactions of phosphatidylethanolamine (PE) by AdoMet, thereby producing phosphatidylcholine (PC).
PathwayPhospholipid metabolism; phosphatidylcholine biosynthesis
SimilarityBelongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein . Mitochondrion membrane ; Multi-pass membrane protein .
Tissue SpecificityLiver.