LMPD Database

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LMP012515

Gene Information

Entrez Gene ID25513
Gene Namephosphoinositide-3-kinase, regulatory subunit 1 (alpha)
Gene SymbolPik3r1
SpeciesRattus norvegicus
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 TAS:ReactomeCcytosol
GO:0016020 IDA:RGDCmembrane
GO:0043005 IDA:RGDCneuron projection
GO:0005634 IDA:RGDCnucleus
GO:0005942 IDA:RGDCphosphatidylinositol 3-kinase complex
GO:0005943 ISS:UniProtKBCphosphatidylinositol 3-kinase complex, class IA
GO:0005886 IDA:RGDCplasma membrane
GO:0043234 IDA:RGDCprotein complex
GO:0016303 TAS:RGDF1-phosphatidylinositol-3-kinase activity
GO:0046935 IDA:RGDF1-phosphatidylinositol-3-kinase regulator activity
GO:0051117 IPI:RGDFATPase binding
GO:0005516 IPI:RGDFcalmodulin binding
GO:0043125 ISS:UniProtKBFErbB-3 class receptor binding
GO:0030331 IPI:RGDFestrogen receptor binding
GO:0005159 ISS:UniProtKBFinsulin-like growth factor receptor binding
GO:0005158 ISS:UniProtKBFinsulin receptor binding
GO:0043560 ISS:UniProtKBFinsulin receptor substrate binding
GO:0043548 IPI:RGDFphosphatidylinositol 3-kinase binding
GO:0035014 ISS:UniProtKBFphosphatidylinositol 3-kinase regulator activity
GO:0051219 IPI:RGDFphosphoprotein binding
GO:0005161 IPI:RGDFplatelet-derived growth factor receptor binding
GO:0008022 IDA:RGDFprotein C-terminus binding
GO:0019904 IPI:RGDFprotein domain specific binding
GO:0019901 IPI:RGDFprotein kinase binding
GO:0005102 IPI:RGDFreceptor binding
GO:0030971 IPI:RGDFreceptor tyrosine kinase binding
GO:0031625 IPI:RGDFubiquitin protein ligase binding
GO:0007568 IEP:RGDPaging
GO:0071398 IEP:RGDPcellular response to fatty acid
GO:0032869 IEP:RGDPcellular response to insulin stimulus
GO:0006006 IMP:RGDPglucose metabolic process
GO:0048009 ISS:UniProtKBPinsulin-like growth factor receptor signaling pathway
GO:0008286 ISS:UniProtKBPinsulin receptor signaling pathway
GO:0045776 IMP:RGDPnegative regulation of blood pressure
GO:0022408 IMP:RGDPnegative regulation of cell-cell adhesion
GO:0010459 IMP:RGDPnegative regulation of heart rate
GO:0010656 IMP:RGDPnegative regulation of muscle cell apoptotic process
GO:0045861 IMP:RGDPnegative regulation of proteolysis
GO:0048662 IMP:RGDPnegative regulation of smooth muscle cell proliferation
GO:0036092 IDA:GOCPphosphatidylinositol-3-phosphate biosynthetic process
GO:0046854 ISS:UniProtKBPphosphatidylinositol phosphorylation
GO:0030335 IMP:RGDPpositive regulation of cell migration
GO:0010628 IMP:RGDPpositive regulation of gene expression
GO:0045663 IMP:RGDPpositive regulation of myoblast differentiation
GO:0001934 IMP:RGDPpositive regulation of protein phosphorylation
GO:0043551 IDA:RGDPregulation of phosphatidylinositol 3-kinase activity
GO:0043200 IEP:RGDPresponse to amino acid
GO:0051591 IDA:RGDPresponse to cAMP
GO:0071548 IEP:RGDPresponse to dexamethasone
GO:0042493 IEP:RGDPresponse to drug
GO:0032355 IEP:RGDPresponse to estradiol
GO:0045471 IEP:RGDPresponse to ethanol
GO:0070542 IEP:RGDPresponse to fatty acid
GO:0009750 IEP:RGDPresponse to fructose
GO:0051384 IDA:RGDPresponse to glucocorticoid
GO:0070848 IEP:RGDPresponse to growth factor
GO:0032868 IDA:RGDPresponse to insulin
GO:0010040 IEP:RGDPresponse to iron(II) ion
GO:0007584 IEP:RGDPresponse to nutrient
GO:0032570 IEP:RGDPresponse to progesterone
GO:0033574 IEP:RGDPresponse to testosterone
GO:0001878 IEP:RGDPresponse to yeast
KEGG Pathway Links
KEGG Pathway IDDescription
ko05221Acute myeloid leukemia
rno05221Acute myeloid leukemia
ko04261Adrenergic signaling in cardiomyocytes
rno04261Adrenergic signaling in cardiomyocytes
ko04960Aldosterone-regulated sodium reabsorption
rno04960Aldosterone-regulated sodium reabsorption
ko05146Amoebiasis
rno05146Amoebiasis
ko04152AMPK signaling pathway
rno04152AMPK signaling pathway
ko04210Apoptosis
rno04210Apoptosis
ko05100Bacterial invasion of epithelial cells
rno05100Bacterial invasion of epithelial cells
ko04662B cell receptor signaling pathway
rno04662B cell receptor signaling pathway
ko04024cAMP signaling pathway
rno04024cAMP signaling pathway
ko04973Carbohydrate digestion and absorption
rno04973Carbohydrate digestion and absorption
ko04022cGMP-PKG signaling pathway
rno04022cGMP-PKG signaling pathway
ko05142Chagas disease (American trypanosomiasis)
rno05142Chagas disease (American trypanosomiasis)
ko04062Chemokine signaling pathway
rno04062Chemokine signaling pathway
rno04725Cholinergic synapse
ko05220Chronic myeloid leukemia
rno05220Chronic myeloid leukemia
ko05210Colorectal cancer
rno05210Colorectal cancer
ko05213Endometrial cancer
rno05213Endometrial cancer
ko05169Epstein-Barr virus infection
rno05169Epstein-Barr virus infection
ko04012ErbB signaling pathway
rno04012ErbB signaling pathway
ko04915Estrogen signaling pathway
rno04915Estrogen signaling pathway
ko04664Fc epsilon RI signaling pathway
rno04664Fc epsilon RI signaling pathway
ko04666Fc gamma R-mediated phagocytosis
rno04666Fc gamma R-mediated phagocytosis
ko04510Focal adhesion
rno04510Focal adhesion
rno04068FoxO signaling pathway
ko05214Glioma
rno05214Glioma
rno05161Hepatitis B
ko05160Hepatitis C
rno05160Hepatitis C
rno04066HIF-1 signaling pathway
ko05166HTLV-I infection
rno05166HTLV-I infection
ko04750Inflammatory mediator regulation of TRP channels
rno04750Inflammatory mediator regulation of TRP channels
ko05164Influenza A
rno05164Influenza A
ko04910Insulin signaling pathway
rno04910Insulin signaling pathway
ko04630Jak-STAT signaling pathway
rno04630Jak-STAT signaling pathway
ko04670Leukocyte transendothelial migration
rno04670Leukocyte transendothelial migration
ko05162Measles
rno05162Measles
ko05218Melanoma
rno05218Melanoma
ko04150mTOR signaling pathway
rno04150mTOR signaling pathway
ko04650Natural killer cell mediated cytotoxicity
rno04650Natural killer cell mediated cytotoxicity
ko04722Neurotrophin signaling pathway
rno04722Neurotrophin signaling pathway
ko04932Non-alcoholic fatty liver disease (NAFLD)
rno04932Non-alcoholic fatty liver disease (NAFLD)
ko05223Non-small cell lung cancer
rno05223Non-small cell lung cancer
ko04380Osteoclast differentiation
rno04380Osteoclast differentiation
ko04921Oxytocin signaling pathway
rno04921Oxytocin signaling pathway
ko05212Pancreatic cancer
rno05212Pancreatic cancer
rno05200Pathways in cancer
ko04070Phosphatidylinositol signaling system
rno04070Phosphatidylinositol signaling system
ko04151PI3K-Akt signaling pathway
rno04151PI3K-Akt signaling pathway
rno04611Platelet activation
ko04914Progesterone-mediated oocyte maturation
rno04914Progesterone-mediated oocyte maturation
ko04917Prolactin signaling pathway
rno04917Prolactin signaling pathway
ko05215Prostate cancer
rno05215Prostate cancer
ko05205Proteoglycans in cancer
rno05205Proteoglycans in cancer
ko04015Rap1 signaling pathway
rno04015Rap1 signaling pathway
rno04014Ras signaling pathway
ko04810Regulation of actin cytoskeleton
rno04810Regulation of actin cytoskeleton
ko05211Renal cell carcinoma
rno05211Renal cell carcinoma
ko04550Signaling pathways regulating pluripotency of stem cells
rno04550Signaling pathways regulating pluripotency of stem cells
ko05222Small cell lung cancer
rno05222Small cell lung cancer
ko04660T cell receptor signaling pathway
rno04660T cell receptor signaling pathway
rno04919Thyroid hormone signaling pathway
ko04668TNF signaling pathway
rno04668TNF signaling pathway
ko04620Toll-like receptor signaling pathway
rno04620Toll-like receptor signaling pathway
ko05145Toxoplasmosis
rno05145Toxoplasmosis
ko04930Type II diabetes mellitus
rno04930Type II diabetes mellitus
ko04370VEGF signaling pathway
rno04370VEGF signaling pathway
ko05203Viral carcinogenesis
rno05203Viral carcinogenesis
REACTOME Pathway Links
REACTOME Pathway IDDescription
5953415Adaptive Immune System
5953413Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
5953991CD28 co-stimulation
5953990CD28 dependent PI3K/Akt signaling
5954063Cell-Cell communication
5953650Cell surface interactions at the vascular wall
5954570Constitutive PI3K/AKT Signaling in Cancer
5953992Costimulation by the CD28 family
5953536Cytokine Signaling in Immune system
5953408DAP12 interactions
5953407DAP12 signaling
5953253Disease
5953994Downstream signaling events of B Cell Receptor (BCR)
5953399Downstream signaling of activated FGFR
5953396Downstream signal transduction
5954035Downstream TCR signaling
5953417Fc epsilon receptor (FCERI) signaling
5953784Fcgamma receptor (FCGR) dependent phagocytosis
5953884GAB1 signalosome
5953641G alpha (12/13) signalling events
5953653G alpha (q) signalling events
5953537Gastrin-CREB signalling pathway via PKC and MAPK
5954278GP1b-IX-V activation signalling
5953642GPCR downstream signaling
5953651GPVI-mediated activation cascade
5953645Hemostasis
5953430IGF1R signaling cascade
5953410Immune System
5953409Innate Immune System
5953422Insulin receptor signalling cascade
5953534Interleukin-2 signaling
5954001Interleukin-3, 5 and GM-CSF signaling
5954308Interleukin-7 signaling
5954000Interleukin receptor SHC signaling
5953428IRS-mediated signalling
5953425IRS-related events
5953429IRS-related events triggered by IGF1R
5953250Metabolism
5953289Metabolism of lipids and lipoproteins
5954128Nephrin interactions
5953394NGF signalling via TRKA from the plasma membrane
5953474Phospholipid metabolism
5953989PI3K/AKT activation
5953997PI3K/AKT Signaling in Cancer
5953885PI-3K cascade
5953432PI3K Cascade
5953996PI3K events in ERBB2 signaling
5953995PI3K events in ERBB4 signaling
5954478PI Metabolism
5953993PIP3 activates AKT signaling
5953644Platelet activation, signaling and aggregation
5954358Regulation of signaling by CBL
5953998Role of LAT2/NTAL/LAB on calcium mobilization
5953783Role of phospholipids in phagocytosis
5954412Signaling by constitutively active EGFR
5953403Signaling by EGFR
5953404Signaling by EGFR in Cancer
5953406Signaling by ERBB2
5953540Signaling by ERBB4
5953400Signaling by FGFR
5954510Signaling by FGFR1 fusion mutants
5954511Signaling by FGFR1 mutants
5953401Signaling by FGFR in disease
5954512Signaling by FGFR mutants
5953391Signaling by GPCR
5953423Signaling by Insulin receptor
5953535Signaling by Interleukins
5953397Signaling by PDGF
5953541Signaling by SCF-KIT
5953414Signaling by the B Cell Receptor (BCR)
5953431Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
5953420Signaling by VEGF
5953395Signalling by NGF
5953381Signal Transduction
5954499Synthesis of PIPs at the plasma membrane
5954036TCR signaling
5954054Tie2 Signaling
5953419VEGFA-VEGFR2 Pathway