LMPD Database

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LMP012521

UniProt Annotations

Entry Information
Gene Nameprostaglandin I2 (prostacyclin) synthase
Protein EntryPTGIS_RAT
UniProt IDQ62969
SpeciesRat
Comments
Comment typeDescription
Catalytic Activity(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15- hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-6,9-alpha-epoxy-11- alpha,15-dihydroxyprosta-5,13-dienoate.
CofactorName=heme; Xref=ChEBI:CHEBI:30413; Evidence= ;
FunctionCatalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2)
SimilarityBelongs to the cytochrome P450 family
Subcellular LocationEndoplasmic reticulum membrane; Single-pass membrane protein.